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Thus, the developed CTCs detection platform demonstrates promising applications for clinical diagnosis.Liquid-phase chromatography on chiral stationary phase is still the most popular and versatile technique to separate enantiomers, which is based on the ability of a chiral selector (CS) to recognize the enantiomers of a chiral compound in a solvating medium. The knowledge of the molecular bases of the enantiodiscrimination process is a basic requirement to approach rationally the enantioseparation task. Indeed, analyte, CS, and mobile phase (MP) being the