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21, 95 % CI 1.10-1.32, p 0.001) and 50 times (aHR 1.48, 95 % CI 1.23-1.77, p 0.001) and the use of inhalants (aHR 1.16, 95 % CI 1.05-1.29). Excessive alcohol intake was not associated with the risk of depression. The results suggest that people who reported to have used cigarettes, alcohol, or drugs at 18 years of age have a moderately increased risk of depression later in life. The results suggest that people who reported to have used cigarettes, alcohol, or drugs at 18 years of age have a moderately increased ris