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The cultivation of terrestrial cyanobacteria showed higher productivities for biomass in the MSSePBR than in suspended systems. Cultivation with increased CO2 contents and flue gas was possible, thus a combination with flue gas treatment is feasible. An up-scaled prototype of the MSSePBR was introduced to show the possibilities for future industrial-sized and facade applications.Aims Rising prevalence of non-communicable diseases world-wide has made diabetes an important comorbidity in patients with coronavirus disease-19 (COVID-19). We