https://www.selleckchem.com/pr....oducts/4-phenylbutyr
Cilia are thought to harbour a membrane diffusion barrier within their transition zone (TZ) that compartmentalises signalling proteins. How this "ciliary gate" assembles and functions remains largely unknown. Contrary to current models, we present evidence that Caenorhabditis elegans MKS-5 (orthologue of mammalian Mks5/Rpgrip1L/Nphp8 and Rpgrip1) may not be a simple structural scaffold for anchoring 10 different proteins at the TZ, but instead, functions as an assembly factor. This activity is needed to form TZ
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