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In this research, the microbial diversity associated with marine sponge Scopalina hapalia had been examined by metagenomic analysis. Twenty-six bacterial and two archaeal phyla were restored from the sponge, of that the Proteobacteria phylum had been the most numerous. In inclusion, 30 isolates from S. hapalia had been chosen and cultivated for recognition and additional metabolites production. The selected isolates were affiliated to the genera

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