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2% mortality rate. Ninety-five were hematological patients, with AML being the most common (57 cases). ConclusionsS. clavata infection in immunosuppressed patients has a poor prognosis middle-age patients, male gender and Acute Myeloid Leukemia should be considered risk factors. In immunosuppressed patients, the clinical presentation can be particularly unusual, imposing difficult differential diagnosis, as in the reported case. Granulocyte colony-stimulating factor (G-CSF) and hypoxia modulate the tumour immune microenvironment. In mo