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In item response theory, uncertainty associated with estimated item parameters can lead to greater uncertainty in subsequent analyses, such as estimating trait scores for individual examinees. Most existing methods to characterize or correct for item parameter uncertainty implicitly assume that the latent trait continuum is fixed across the posterior distribution of item parameters. However, the latent trait continuum can also be understood as an artifact of the fitted model, such that the location of this continuum is determined with

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4% ID/g) and HSA-Tt-[99mTc-HyNic] (4.6% ID/g) was detected at 24 h postinjection. In vivo treatment studies were performed in the same HER2(+) breast cancer model using PET-SPECT image guidance. The increased tumor uptake of the pretargeting and drug delivery components was detected by PET-CT and SPECT-CT, respectively. The study showed a significant 92% reduction of the relative tumor volume in treated mice (RTV = 0.08 in 26 days), compared to the untreated control mice (RTV = 1.78 in 11 days) and to mice treated wit