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Experiments and theories showed the ground-state reaction F + H2O → HF + OH possesses Feshbach resonances trapped in the hydrogen bond well in the product region. However, it is not clear whether F + H2O and its isotopic analogues have the same Feshbach resonances caused by chemical bond softening as those in the F + H2/HD. Here, we reported state-to-state quantum dynamics studies of the F + HOD(vOH = 1) → HF + OD and F + HOD(vOD = 1) → DF + OH reactions on an accurate neural network potential energy surface. Detailed analysis reveals th