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First Line Treatment For ADHD in Adults Some people with ADHD discover that medication can help to manage their symptoms. The stimulants, like amphetamine and methylphenidate, are effective in boosting activity in the brain regions that regulate attention and behavior. Other medications, such as the nonstimulant drug atomoxetine, and antidepressants that work differently, but are still effective. Regular visits to the GP is recommended for patients who take medications. They can adjust dosages and check for the body's reactions. Medication Adults o