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of catheter-related limb ischemia in patients with VA-ECMO. Due to the small amount of studies and the influence of population heterogeneity and other factors, more large-sample and high-quality randomized controlled trial (RCT) studies are still needed. To compare the effect of goal-directed fluid resuscitation and bedside ultrasound-guided fluid resuscitation in patients with septic shock, and to evaluate the application value of bedside ultrasound in fluid resuscitation of patients with septic shock. Forty patients with septic shock