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TECHNIQUES Here, we sought to handle this need by developing a model to analyze metastatic breast cancer cell-microglial interactions making use of intravital imaging coupled with ex vivo electrophysiology. We implanted an optical window regarding the parietal bone tissue to facilitate observance of cellular behavior in situ within the outer cortex of heterozygous Cx3cr1GFP/+ mice. RESULTS We detected GFP-expressing microglia in Cx3cr1GFP/+ mice up to 350 μm below the window with

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Secondary caries is the primary cause of composite restoration failures, resulting from marginal leakage and bacterial accumulation in the oral environment. Antibacterial dental composites, especially antibacterial monomers, have emerged as a promising strategy to inhibit secondary caries, which is pivotal to prolonging the lifespan of dental restorations. In this work, monomethacrylate- and dimethacrylate-functionalized betulin derivatives (M1Bet and M2Bet) were synthesized via an esterification reaction and served as antibacterial como