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An in-depth analysis for the fundamental signaling events revealed that β-catenin-mediated transcriptional activation of FOS-like antigen 2 (FOSL2) and repression regarding the AT-rich interaction domain 5A (ARID5A) drive gene regulating switch from M1-like TAMs to M2-like TAMs. Moreover, we unearthed that large expressions of β-catenin and FOSL2 correlated with poor prognosis in customers with lung cancer tumors. In conclusion, β-catenin drives a transcriptional s