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The suitability of the method was shown by the comparison of 35 anonymized leftover serum samples from intensive care patients with routine analyses. For the first time, we herein describe a liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of meropenem and its ORM in human serum. The ratio of active to inactive compound provides valuable pharmaceutical and pharmacokinetic information, which may contribute to therapeutic efficacy. For the first time, we herein describe a liquid chromat
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