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In addition, histological lesions were found in the liver, intestine, and gill of the exposed fish. The severity of lesions showed a size and dose-dependent pattern. Polystyrene induced the antioxidant system of exposed fish through elevating the levels of SOD and CAT activity and significant difference in expression of antioxidant related genes (CAT, SOD and HSP7. In conclusion, the results of the present study confirmed the toxic effects of microplastic, polystyrene on goldfish.In this study, the adsorption of cesium (Cs) on biotite a