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In this short review, we ask the question do antibacterial agents derived from plants have a chance to become a panacea against infectious diseases in the "post-antibiotics era".Genetic code expansion is a powerful tool for the study of protein interactions, as it allows for the site-specific incorporation of a photoreactive group via non-canonical amino acids. Recently, several groups have published bifunctional amino acids that carry a handle for click chemistry in addition to the photo-crosslinker. This allows for the specific label