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No patient needed mesh explantation for persistent infection of the mesh. During a median follow-up of 13months, 4 of 46 ventral hernia patients (8.7%) developed a CT confirmed hernia recurrence. Polypropylene reinforced tissue matrix can withstand infectious complications and provides acceptable mid-term recurrence rates in this retrospective study on open complex abdominal wall reconstructions. Longer follow-up data from prospective studies are required to determine further risk of hernia recurrence. Polypropylene reinforced tissue matri