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This study seeks to define long-term variation in body composition in patients undergoing esophagectomy for cancer and to associate those changes with survival. Assessment of skeletal muscle, visceral (VAT) and subcutaneous adipose tissue (SAT) was performed using computed tomography (CT) images routinely acquired at diagnosis; after neoadjuvant therapy, and; 6 months after esophagectomy. In cases where multiple CT scans were performed 6 months after surgery, all available images were assessed. Ninty-seven patients met inclusion