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Copyright © 2020 Mitri, Bischoff, Belda Cuesta, Volant, Ghozlane, Eiglmeier, Holm, Dieme, Brito-Fravallo, Guelbeogo, Sagnon, Riehle and Vernick.Ebolavirus (EBOV) infection in humans causes severe hemorrhagic fevers with high mortality rates that range from 30 to 80% as shown in different outbreaks. Thus the development of safe and efficacious EBOV vaccines remains an important goal for biomedical research. We have shown in early studies that immunization with insect cell-produced EBOV virus-like particles (VLPs) is able to induce prote