https://paeoniflorininhibitor.....com/ecotoxicity-asso
The design task would be to combine in the same molecule the thiazolo[5,4-d]pyrimidine core, an essential pharmacophoric feature to block the A2A AR, with a benzenesulfonamide group which will be a characteristic set of CD73 inhibitors. Almost all of the reported substances triggered inverse agonists regarding the real human (h) A2A AR endowed with a high affinity, selectivity and potency. However they had been poor inhibitors of CD73 enzyme. Nonetheless, this study can be
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