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Additionally, the results of metabolic stability, CYP, PK research in vivo, acute poisoning study and subacute toxicity evaluation indicated this ingredient had good drug-like properties for treatment.A brand new series of sulfonamide endowed with hydrazone coupled to dimethyl and/or diethyl malonates were prepared. Numerous sulfa medications had been diazotized and followed by coupling with active methylene of dimethyl and/or diethyl malonate to cove
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