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01, OR = 1.04) and PSAD (P 0.01, OR = 10.04), negatively with the prostate volume (P 0.01, OR = 0.98) and ICI (P 0.01, OR = 0.22), but not with BMI (P 0.05). As a predictor of positive prostate biopsy, tPSA 10 μg/L exhibited a sensitivity of 82.14% and a specificity of 35.71%, while PSAD 0.26 showed a sensitivity of 78.57% and a specificity of 71.43%. Non-specific elevation of the tPSA level induced by increased prostate volume and inflammatory cell infiltration may lead to unnecessary biopsies in some patient