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051, P=0.003). Two-sample MR results further confirmed the causal effect between gut microbial synthesis of the SCFA butyrate and appendicular lean mass (β=0.06, 95% confidence interval 0 to 0.13, P=0.06). Our results may help the future development of novel intervention approaches for preventing or alleviating loss of SMM. Our results may help the future development of novel intervention approaches for preventing or alleviating loss of SMM. Endoscopic submucosal dissection (ESD) and endoscopic mucosal resection (EMR) are two common procedures used for rese