https://www.selleckchem.com/pr....oducts/exarafenib.ht
Additionally, N-propargylpiperidine 16 is an irreversible and time-dependent inhibitor of MAO-B, while N-benzylpiperidine 10 is reversible. Additionally, compounds 10, 13, 16, and 22 should be able to cross the blood-brain barrier and are not cytotoxic to human neuronal-like SH-SY5Y and liver HepG2 cells. Finally, compounds 10 and 16 also prevent amyloid β1-42 (Aβ1-42)-induced neuronal cell death. The neuroprotective effects of compound 16 could be the result of its Aβ1-42 anti-aggregation effects.Long regarded as a disease exclusive
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