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8%; P less then 0.0001 and 7.2%; P=0.0042, respectively). There was a significant improvement in the OS rate for patients beginning targeted therapy after 2011 compared with those starting therapy prior to 2010. The 50% OS rate in patients starting targeted therapy before 2010 and after 2011 was, respectively, 17.1 and 38.6 months for the older-aged group (P=0.0066), while there was no significant difference for the younger-aged group (P=0.1441; 50% OS; 35.9 vs. 30.5 months). The results of the present study indicated that the

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Several Ca2+-permeable cation channels attract attention for their mechanotransducer function to evoke Ca2+ signals in cell invasion. Vellino et al., have clarified the versatility of the osmo-sensing TRPV4 channel in regulating invadosome functions TRPV4 detects and integrates multiple cellular and environmental cues, triggering Ca2+ signals and molecular interactions that modulate coupling between acto-adhesion and extracellular matrix degradation.Phase-contrast magnetic resonance velocimetry (PC-MRI) has been widely used to investigat