https://www.selleckchem.com/pr....oducts/gkt137831.htm
H2S and nitric oxide levels upsurge in DMH-treated rats and promoted preneoplastic damage. Histopathologically, loss of crypts, goblet cells, and distorted lamina propria were observed in toxic group. Treatment with roflumilast was able to curtail down oxidative stress and inflammatory markers and stabilitate the hemodynamic derangements as well as was able to restore the normal architecture of colonic mucosa. Conclusion The findings from the present study conclude that treatment with roflumilast positively modulates the preneoplastic
Like
Comment
Share
