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Finally, we verified that knockdown of Trim21 markedly reduced a certain type of skin lesions (plaques). Thus, our study substantiated that the increased expression of Trim21 in the skin of psoriasis patients could contribute to inflammation. Trim21 could be a potential target in the treatment of psoriasis. Linked Article Yang et al. Br J Dermatol 2021; 184111-122.Identifying the general principles that shape mechanisms of collective decision-making requires studies that span a diversity of ecological contexts. However, collective decis