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1 (1.4-6.6)), interstitial lung disease(OR 3.2 (1.1-9.7)) and pulmonary arterial hypertension(OR 5.25 (1.69-16.36)). ATA positivity was associated with more severe microangiopathy(OR 2.09 (1.05-4.13)). Patients that solely expressed ACA IgG showed a trend towards less severe microangiopathy compared to patients expressing also ACA IgM and/or IgA, levels of ACA IgG and ATA IgM associated with microangiopathy severity. Conclusion We observed an association between ACA and ATA responses and the degree of microangiopathy in SSc. These findings