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111, P = 0.046). CONCLUSIONS Stereotactic body radiation therapy was an excellent ablative treatment option for patients with small HCC. Tumor size was a significant factor for local tumor control after SBRT, although the total dose was negatively correlated with tumor size. Considering the low OS rates and the high local tumor control rates, the combined SBRT and systemic therapies may be beneficial for improving survival outcomes. © 2020 Journal of Gastroenterology and Hepatology Foundation and John Wiley Sons Australia, Ltd.Hepatit

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We thank Drs. Jindal and Sarin for their correspondence regarding our study of the nonsteroidal FXR agonist cilofexor in NASH. The objective of this Phase 2a study was to obtain preliminary evidence regarding the safety, pharmacokinetics, pharmacodynamics, and efficacy of cilofexor, including dose response. Indeed, our observations informed the 48-week ATLAS trial of cilofexor as monotherapy and in combination with other compounds that includes histologic endpoints (NCT03449446). Although reductions in liver transaminases wer