https://www.selleckchem.com/pr....oducts/chk2-inhibito
KEY POINTS Ketamine is a common anesthetic agent used in research and more recently as medication in treatment of depression. It has known effects on inhibition of interneurons and cortical stimulus-locked responses, the underlying functional network mechanisms are still elusive. Analyzing population activity across all layers within the auditory cortex, we found that with anesthetic doses it induces a stronger activation and stimulus- locked response to pure-tone stimuli. This cortical response is driven by gain enhanc
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