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42; 95% confidence interval [95% CI] 0.67-4.17; = 0.008) and risperidone group (3.40; 95% CI 0.54-6.25; = 0.021). Urinary melatonin was significantly decreased in both haloperidol ( = 0.005) and risperidone group ( = 0.014). PSQI score was significantly increased in both haloperidol ( = 0.001) and risperidone group ( = 0.003). Serum GAP-43 was significantly decreased in both haloperidol and risperidone group ( 0.001). PANSS decreased significantly in both the groups and there was a significant negative correlation between serum melat