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Characteristics of patients, transplantation modalities, and aGVHD severity were similar in both groups. The 1-year OS was better after DE (54% vs. 5%, P = 0.0004). The 2-year OS was also better in "Enterostomy group" (31% vs. 2.5%; P = 0.0015), with a trend to lower death by sepsis (30.8% vs. 57.9%; P = 0.091). DE should be considered for severe GI-aGVHD as soon as resistance to the corticosteroid is identified. DE should be considered for severe GI-aGVHD as soon as resistance to the corticosteroid is identified. to compare Chronic Po