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Univariate logistic regression analysis revealed that C-reactive protein, DIC score ≥2 and LLR 345 were the factors associated with prognosis. Multivariate analysis showed that only LLR 345 was an independent risk factor for prognosis (odds ratio [OR] = 9.176, 95% confidence interval [CI] 2.674-31.487, P  .001). Lastly, we confirmed that LLR was also an independent risk factor for prognosis in severe COVID-19 patients in the validation cohort where the AUC was 0.857 (95% CI 0.718-0.997).LLR is an accurate predictive score fo

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