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ADHD in Adults Treatment ADHD is associated with significant impairments of academic performance and social functioning. Adults with ADHD are at a higher risk of developing anxiety disorders, depression and substance abuse. The use of medications to treat the core ADHD symptoms are shown to work by increasing the amount of neurotransmitters responsible for controlling the impulsivity and attention. Medication trials are usually conducted to determine which drugs and at what dosages are most effective for each