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Since rats with only p52Shc knockout do not display the phenotype of p52Shc/p46Shc-KO, abnormal locomotion is likely to be caused by p46Shc deletion. Our data suggest a previously unknown role of 46Shc actions and signaling in regulation of gait.With growing scientific evidence showing the harmful impact of air pollution on the environment and individuals' health in modern societies, public concern about air pollution has become a central focus of the development of air pollution prevention policy. Past research has shown that social media
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