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5 per 100 patient-years). The incidence density of thromboembolic events was significantly increased in the INR level below 2.00 (P = .03), while the INR level of 3.50 or more was significantly increased in the incidence density of major bleeding events (P = .03). Total bleeding and minor bleeding were increased significantly in INR level of 2.50 or more (P = .04). Conclusions The INR of 2.00 to 2.49 was appeared to be associated with the lowest incidence density of thromboembolic and bleeding events in these patients.Introduction R

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ated the prognosis of C-SCLCs did not significantly differ from that of P-SCLCs, but was more susceptible to the extent of resection. Patients with C-SCLC who underwent limited resection had a significantly increased risk of shorter OS. This study highlighted the importance of performing lobectomy for resectable C-SCLC patients. This study also proved the benefit of PCI in improving the OS rate for both P-SCLC and C-SCLC patients.Programmed cell death receptor-1 and its ligand-1 (PD-1/PD-L1) inhibitors have been applied to many cancers,