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Practices We evaluated treated an HIV-infected guy with cirrhosis from genotype 1b HCV who had failed 3 DAA regimens. Results We treated and cured our "particularly difficult-to-cure" patient with sofosbuvir plus glecaprevir/pibrentasvir plus ribavirin for 24 months. We discuss the literary works on possible biological factors behind their therapy failures such as for example lack of HCV seroconversion during his illness course, and several failures of hepatitis B seroconversion after v