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Implications this research describes a novel agent, pHLIP-αKu80(γ), which combines peptide nucleic acid (PNA) antisense and pH-low insertion peptide (pHLIP) technologies to selectively lessen the appearance associated with DNA repair factor KU80 in tumors and confer tumor-selective radiosensitization. Copyright ©2020, United states Association for Cancer Research.Through the use of an unbiased, genome-scale CRISPR modifier display, we identified NF1 suppression as a mechanism of r
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