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This study suggests that safe school reopening requires the strict maintenance of public health measures in the community.Three eco-friendly spectrophotometric methods were developed for determination of the novel anticoagulant drug, betrixaban (BTX). The first method (method A) was based on direct analysis of BTX at 229.4 nm on the zero-order spectrum using methanol as the optimum solvent. While the second method (method was based on measuring difference absorption value (ΔA) of BTX at 335 nm, which was obtained from pH-induced spec