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BACKGROUND The high morbidity and mortality caused by influenza viruses translate into a great impact on specialized health care. Apart from the annual vaccination, the relevance of other measures to prevent and control this infection is unknown. The objective of our research was to determine the importance of a real-time surveillance system to establish early extended transmission precautions. METHODS Quasi-experimental before-and-after study comparing the influenza cases detected in hospitalized adults during the 2016/2017 season (26