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05). Multivariate analyses showed that synchronous adenoma (HR =2.515, 95% CI 1.691-3.742, P0.01); stage II (HR =2.066, 95% CI 1.329-3.210, P0.01); and left-side colorectal resection (HR =2.207, 95% CI 1.292-3.772, P0.01) were independent risk factors. Synchronous adenoma, left-side colorectal resection, and stage II cancer are independent risk factors of metachronous adenoma in patients with previous stage I and II CRC. In patients with risk factors, an enhanced colonoscopic strategy might be needed for early detection