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5 L·min-1 followed by a reduction (second-order polynomial R2 =0.27). After accounting for a hypoxemia-induced decrease in arterial O2 content with increasing V ˙ O2max (R2 =0.17; P less then 0.001), systemic O2 extraction fraction increased up to ~90% ( V ˙ O2max 4.5 L·min-1 ) with no further change (exponential decay model R2 =0.42). Likewise, leg O2 extraction fraction increased with V ˙ O2max to approach a maximal value of ~90-95% (R2 =0.83). Muscle O2 diffusing capacity and the equilibration index Y increased linearly with V ˙ O2ma
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