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The aim of this study was to develop a single blood test that could determine gestational age and estimate the risk of preterm birth by measuring serum metabolites. We hypothesised that serial metabolic modelling of serum analytes throughout pregnancy could be used to describe fetal gestational age and project preterm birth with a high degree of precision. A retrospective cohort study. Two medical centres from the USA. Thirty-six patients (20 full-term, 16 preterm) enrolled at Stanford University were used to develop gestational age an