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Cotherapy has an efficient anticancer impact by enhancing apoptosis and autophagy, resulting in reducing tumefaction mobile viability and ascites liquid amount together with downregulation of Bcl2 protein phrase. This cotherapy increases Beclin 1 and INFγ and decreases IL-13. ZnO NPs upregulate COX2 appearance, whereas TQ downregulates its expression. High-dose ZnO NPs have more toxic effects on liver enzymes. Utilizing TQ along with ZnO NPs can eliminate ZnO NPs liver toxicity. The cothera