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This method would provide great potential in applications which require high resolution volume imaging.A nanosecond-millisecond combined pulse laser (CPL) drilling method was proposed for drilling alumina ceramic. The total energy consumption of the CPL drilling was 1/7 of that of a conventional millisecond laser, and the drilling quality was better. The simulation results demonstrated that, due to the nonuniform reflection of the millisecond laser in the keyhole, the ellipse keyhole ablated by the off-axis incident nanosecond pulses had no