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After explaining the important pre-analytical safety measures required for a sufficient evaluation, the immunophenotypic features of small-cell and large-cell lymphomas are described in this review. The ubiquitous phrase of CD19 is a first mandatory gating step. A potential clonal expansion is then suspected by the demonstration of surface immunoglobulin light string constraint. The aberrant presence of CD5 permits to segregate chronic lymphocytic leukemia and mantle cell lymphoma in most cases. Vari