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How a VC Can Affect Your Heart PVCs are commonplace and can be experienced by a variety of people without causing any problems. If they occur often, PVCs may weaken your heart and increase your chance of suffering from heart failure. A bundle of fibers located in the upper right-hand corner of your heart (the sinoatrial node, also known as SA) typically controls the heart's rhythm. Electrical signals are transmitted to the lower heart chambers or ventricles. Causes PVCs are caused when the electrical impulse that normally