https://www.selleckchem.com/pr....oducts/guanosine-5-t
Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia of children with systemic involvement and poor outcome. The altered RAS-RAF-MEK-ERK cell signalling pathway due to somatic mutation of BRAF V600E is the most common genetic abnormality associated with the disease. In the current study, we highlight the frequency of BRAF V600E in our cohort of LCH cases (n = 31) and its relation with clinical outcome. On Real-Time PCR and Sanger sequencing, BRAF V600E was detected in 6/31 (19%) patien

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Symptoms of ADHD in Adults Many people who suffer from ADHD go through their entire lives without being diagnosed. They might even be misdiagnosed with other conditions. They may be relieved to know that they're not 'lazy or inflexible'. They may also feel frustrated that their problems were not recognized and addressed earlier. 1. Lack of Focus ADHD is typically associated with difficulty in staying focused. It is a condition that can last for a lifetime, but it can become problematic as people get older and take on more obligations. It can affect your relat