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To this end, the defective APP-mRNA isoform responsible for the disease in cells and tissues appears as an ideal target for epigenetic therapeutic intervention and antisense drugs are potential treatment. © 2019 the Author(s), licensee AIMS Press.The combination of Artificial Neural Networks and Fuzzy Logic Systems enables the representation of real-world problems via the creation of intelligent and adaptive systems. By adapting the interconnections between layers, Artificial Neural networks are able to learn. A computing framework based

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