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Additionally, we identify the key residues located in antagonist ZM241385 binding pocket which mediate multiple allosteric pathways and have been experimentally proven to play a critical role in affecting the ligand potency. This study is helpful for understanding the allosteric communication mechanism of A2AAR, and can provide valuable information for the structure-based drug design of GPCRs. Communicated by Ramaswamy H. Sarma.Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genom

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Size and density of resulting Au clusters strongly depend on substrate material and morphology. Au ELD is shown to proceed through a galvanic displacement on Ni substrate, and it can be modeled with a local cell mechanism widely affected by the substrate conductivity at surface. These data are presented and discussed, allowing for cheap and reproducible Au nanoparticle decoration on several substrates.The advancements of magnetic resonance imaging contrast agents (MRCAs) are continuously driven by the critical needs for early detection