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Background and study aims The majority of patients with symptomatic sterile walled-off necrosis can be treated conservatively. Although endoscopic transluminal drainage is often performed in case of persistent symptoms, post-procedural iatrogenic infection may occur. The aim of this study was to evaluate the clinical outcome after endoscopic transluminal drainage of symptomatic sterile walled-off necrosis. Patients and methods Retrospective, multicenter, open-label case series of 56 patients with necrotizing pancreatitis who were drained endoscopically for